InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKL2

Summary

InnateDB Protein

IDBP-15209.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKL2

Protein Name

MKL/myocardin-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339086

InnateDB Gene

IDBG-15207 (MKL2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269PubMed:14565952}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving C11orf95 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with C11orf95 produces a C11orf95-MKL2 fusion protein (PubMed:20607705). {ECO:0000269PubMed:20607705}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0007517	muscle organ development
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0045844	positive regulation of striated muscle tissue development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0048568	embryonic organ development
GO:0048738	cardiac muscle tissue development
GO:0051145	smooth muscle cell differentiation