InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLN2

Summary

InnateDB Protein

IDBP-15262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLN2

Protein Name

talin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303476

InnateDB Gene

IDBG-15260 (TLN2)

Protein Structure

UniProt Annotation

Function

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005158	insulin receptor binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007043	cell-cell junction assembly
GO:0007155	cell adhesion

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR002404 Insulin receptor substrate-1, PTB
IPR002558 I/LWEQ domain
IPR006077 Vinculin/alpha-catenin
IPR015009 Vinculin-binding site-containing domain
IPR015224 Talin, central
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM