InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spon2

Summary

InnateDB Protein

IDBP-152786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spon2

Protein Name

spondin 2, extracellular matrix protein

Synonyms

2310045I24Rik; AI504350; M-spondin; Mindin; Mspondin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042701

InnateDB Gene

IDBG-152784 (Spon2)

Protein Structure

UniProt Annotation

Function

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens. {ECO:0000269PubMed:14691481}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:14691481}.

Disease Associations

Tissue Specificity

Detected in heart, lung, thymus, spleen and lymph node. {ECO:0000269PubMed:14691481}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002448	mast cell mediated immunity
GO:0007155	cell adhesion
GO:0008228	opsonization
GO:0032496	response to lipopolysaccharide
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042742	defense response to bacterium
GO:0043152	induction of bacterial agglutination
GO:0045087	innate immune response
GO:0050832	defense response to fungus
GO:0051607	defense response to virus
GO:0060907	positive regulation of macrophage cytokine production
GO:0071222	cellular response to lipopolysaccharide