Version 5.4
Mus musculus Gene: Spon2
Summary
InnateDB Gene IDBG-152784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spon2
Gene Name spondin 2, extracellular matrix protein
Synonyms 2310045I24Rik; AI504350; M-spondin; Mindin; Mspondin
Species Mus musculus
Ensembl Gene ENSMUSG00000037379
Encoded Proteins
IDBP-152786
spondin 2, extracellular matrix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20205276
[Homo sapiens] SPON2 expression is upregulated during intestinal inflammation and may induce NF-kappaB promoter activation in a TLR-9 mediated manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159674:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33213518-33218238
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000046186 ENSMUSP00000042701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002448 mast cell mediated immunity
GO:0007155 cell adhesion
GO:0008228 opsonization
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042742 defense response to bacterium
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0060907 positive regulation of macrophage cytokine production
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159674
View Gene Order
ENSBTAG00000004261
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt Q8BMS2
TrEMBL Q6KAS6
UniProt Splice Variant
Entrez Gene 100689
UniGene Mm.34694
RefSeq NM_133903 XM_006503622
OMIM
CCDS CCDS19200
HPRD
IMGT
MGI ID MGI:1923724
MGI Symbol Spon2
EMBL AK028987 AK131131 AY457639
GenPept AAR20834 BAC26226 BAD21381
RNA Seq Atlas 100689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca