Mus musculus Gene: Spon2
Summary
InnateDB Gene IDBG-152784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spon2
Gene Name spondin 2, extracellular matrix protein
Synonyms 2310045I24Rik; AI504350; M-spondin; Mindin; Mspondin;
Species Mus musculus
Ensembl Gene ENSMUSG00000037379
Encoded Proteins
spondin 2, extracellular matrix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SPON2 expression is upregulated during intestinal inflammation and may induce NF-kappaB promoter activation in a TLR-9 mediated manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159674:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33213518-33218238
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000046186 ENSMUSP00000042701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002448 mast cell mediated immunity
GO:0007155 cell adhesion
GO:0008228 opsonization
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042742 defense response to bacterium
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0060907 positive regulation of macrophage cytokine production
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Beta2 integrin cell surface interactions
Cross-References
SwissProt Q8BMS2
TrEMBL Q6KAS6
UniProt Splice Variant
Entrez Gene 100689
UniGene Mm.34694
RefSeq NM_133903 XM_006503622
OMIM
CCDS CCDS19200
HPRD
IMGT
MGI ID MGI:1923724
MGI Symbol Spon2
EMBL AK028987 AK131131 AY457639
GenPept AAR20834 BAC26226 BAD21381
RNA Seq Atlas 100689