Version 5.4
Homo sapiens Protein: H2AFV
Summary
InnateDB Protein IDBP-15295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2AFV
Protein Name H2A histone family, member V
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308405
InnateDB Gene IDBG-15289 (H2AFV)
Protein Structure
UniProt Annotation
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002119 Histone H2A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q71UI9
PhosphoSite PhosphoSite-Q71UI9
TrEMBL
UniProt Splice Variant
Entrez Gene 94239
UniGene Hs.628079
RefSeq NP_036544
HUGO HGNC:20664
OMIM
CCDS CCDS5496
HPRD 13623
IMGT
EMBL AB209001 AC004854 AF081192 AK023973 BC000098 BC004274 BC014885 BC070169 BE742590 BU543626 CH471128
GenPept AAC31938 AAH00098 AAH04274 AAH14885 AAH70169 AAS00365 BAD92238 BAG51243 EAW61075 EAW61077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca