InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppid

Summary

InnateDB Protein

IDBP-153116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppid

Protein Name

peptidylprolyl isomerase D (cyclophilin D)

Synonyms

4930564J03Rik; CYP-40; Ppidl; Ppif;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029382

InnateDB Gene

IDBG-153114 (Ppid)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis. {ECO:0000269PubMed:18771283}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0008134	transcription factor binding
GO:0030331	estrogen receptor binding
GO:0030544	Hsp70 protein binding
GO:0031072	heat shock protein binding
GO:0042277	peptide binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0015031	protein transport
GO:0034389	lipid particle organization
GO:0043065	positive regulation of apoptotic process
GO:0045070	positive regulation of viral genome replication
GO:0050714	positive regulation of protein secretion
GO:0061077	chaperone-mediated protein folding
GO:0071492	cellular response to UV-A

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1914988

InterPro

IPR001440 Tetratricopeptide TPR1
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
IPR029000 Cyclophilin-like domain

PFAM

PF00515
PF00160
PF13174
PF13176
PF13181

PRINTS

PR00153

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt