InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa8

Summary

InnateDB Protein

IDBP-153615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa8

Protein Name

heat shock protein 8

Synonyms

2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015800

InnateDB Gene

IDBG-153613 (Hspa8)

Protein Structure

UniProt Annotation

Function

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 255 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	255 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0023026	MHC class II protein complex binding
GO:0031072	heat shock protein binding
GO:0042623	ATPase activity, coupled
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0006950	response to stress
GO:0008380	RNA splicing
GO:0042026	protein refolding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051726	regulation of cell cycle
GO:0072318	clathrin coat disassembly
GO:1902904	negative regulation of fibril organization

Cellular Component

GO:0000974	Prp19 complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:105384

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63017