Mus musculus Protein: Hspa8
InnateDB Protein IDBP-153615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hspa8
Protein Name heat shock protein 8
Synonyms 2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10;
Species Mus musculus
Ensembl Protein ENSMUSP00000015800
InnateDB Gene IDBG-153613 (Hspa8)
Protein Structure
UniProt Annotation
Function Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 255 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 255 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0023026 MHC class II protein complex binding
GO:0031072 heat shock protein binding
GO:0042623 ATPase activity, coupled
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0006950 response to stress
GO:0008380 RNA splicing
GO:0042026 protein refolding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051726 regulation of cell cycle
GO:0072318 clathrin coat disassembly
GO:1902904 negative regulation of fibril organization
Cellular Component
GO:0000974 Prp19 complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:105384
InterPro IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain
PFAM PF06723
Post-translational Modifications
SwissProt P63017
PhosphoSite PhosphoSite-P63017
UniProt Splice Variant
Entrez Gene 15481
UniGene Mm.472965
RefSeq NP_112442
MGI Symbol Hspa8
EMBL AC158355 AK035286 AK075935 AK135281 AK145579 AK146708 AK146985 AK147864 AK150474 AK150498 AK150701 AK150846 AK150958 AK151065 AK151127 AK151287 AK151435 AK151516 AK151537 AK151775 AK151808 AK151865 AK151892 AK151948 AK151997 AK152598 AK152697 AK152703 AK152803 AK153032 AK153834 AK159479 AK164000 AK166643 AK166721 AK166767 AK166776 AK166808 AK166830 AK166846 AK166861 AK166873 AK166908 AK166910 AK166913 AK166933 AK167043 AK167121 AK167122 AK167134 AK167163 AK167218 AK167229 AK167845 AK167910 AK168492 AK168519 AK168542 AK168711 AK168750 AK168776 AK168887 AK168934 AK169093 AK169179 AK169236 AK169293 AK171434 BC006722 BC066191 BC085486 BC089322 BC089457 BC106169 BC106193 M19141 U27129 U73744 X05837 X54401 X54402 X54403
GenPept AAA37869 AAB18391 AAC52836 AAH06722 AAH66191 AAH85486 AAH89322 AAH89457 AAI06170 AAI06194 BAC29016 BAC36065 BAE22472 BAE26523 BAE27374 BAE27588 BAE28187 BAE29591 BAE29612 BAE29780 BAE29904 BAE29990 BAE30081 BAE30135 BAE30272 BAE30398 BAE30465 BAE30484 BAE30681 BAE30707 BAE30753 BAE30776 BAE30822 BAE30861 BAE31346 BAE31427 BAE31432 BAE31508 BAE31664 BAE32204 BAE35116 BAE37581 BAE38912 BAE38970 BAE39005 BAE39012 BAE39036 BAE39053 BAE39065 BAE39076 BAE39084 BAE39109 BAE39111 BAE39113 BAE39127 BAE39211 BAE39269 BAE39270 BAE39280 BAE39304 BAE39344 BAE39353 BAE39865 BAE39917 BAE40379 BAE40398 BAE40419 BAE40553 BAE40590 BAE40612 BAE40704 BAE40745 BAE40876 BAE40957 BAE41004 BAE41049 BAE42451 CAA38267 CAA38268 CAA38269 CAB57815