Mus musculus Gene: Hspa8
Summary
InnateDB Gene IDBG-153613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hspa8
Gene Name heat shock protein 8
Synonyms 2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10;
Species Mus musculus
Ensembl Gene ENSMUSG00000015656
Encoded Proteins
heat shock protein 8
heat shock protein 8
heat shock protein 8
heat shock protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109971:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:40800984-40805200
Strand Forward strand
Band A5.1
Transcripts
ENSMUST00000015800 ENSMUSP00000015800
ENSMUST00000117870 ENSMUSP00000114081
ENSMUST00000117557 ENSMUSP00000113722
ENSMUST00000149936
ENSMUST00000153847
ENSMUST00000140984
ENSMUST00000138895
ENSMUST00000133964 ENSMUSP00000117285
ENSMUST00000127699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 255 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 255 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0023026 MHC class II protein complex binding
GO:0031072 heat shock protein binding
GO:0042623 ATPase activity, coupled
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0006950 response to stress
GO:0008380 RNA splicing
GO:0042026 protein refolding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051726 regulation of cell cycle
GO:0072318 clathrin coat disassembly
GO:1902904 negative regulation of fibril organization
Cellular Component
GO:0000974 Prp19 complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
Membrane Trafficking pathway
GABA synthesis, release, reuptake and degradation pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cellular responses to stress pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Lysosome Vesicle Biogenesis pathway
Golgi Associated Vesicle Biogenesis pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Neurotransmitter Release Cycle pathway
Attenuation phase pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Gene Expression pathway
Neuronal System pathway
mRNA Splicing - Major Pathway pathway
Regulation of HSF1-mediated heat shock response pathway
Transmission across Chemical Synapses pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
MAPK signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Endocytosis pathway
Antigen processing and presentation pathway
Toxoplasmosis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
RANKL pathway
TSH pathway
REACTOME
Cellular responses to stress pathway
Developmental Biology pathway
trans-Golgi Network Vesicle Budding pathway
Regulation of HSF1-mediated heat shock response pathway
CHL1 interactions pathway
Neuronal System pathway
Attenuation phase pathway
Axon guidance pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
GABA synthesis, release, reuptake and degradation pathway
Clathrin derived vesicle budding pathway
HSF1-dependent transactivation pathway
Golgi Associated Vesicle Biogenesis pathway
Cellular response to heat stress pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
Neurotransmitter Release Cycle pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Lysosome Vesicle Biogenesis pathway
mRNA Splicing pathway
Gene Expression pathway
Membrane Trafficking pathway
mRNA Splicing - Major Pathway pathway
Regulation of HSF1-mediated heat shock response pathway
mRNA Splicing - Major Pathway pathway
HSF1-dependent transactivation pathway
mRNA Splicing pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
L1CAM interactions pathway
Cellular responses to stress pathway
Gene Expression pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Axon guidance pathway
Cellular response to heat stress pathway
CHL1 interactions pathway
Attenuation phase pathway
Developmental Biology pathway
KEGG
Spliceosome pathway
MAPK signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Endocytosis pathway
Antigen processing and presentation pathway
Toxoplasmosis pathway
INOH
PID BIOCARTA
PID NCI
C-MYB transcription factor network
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL D3Z5E2
UniProt Splice Variant
Entrez Gene 15481
UniGene Mm.290774 Mm.336743 Mm.426378 Mm.472965
RefSeq NM_031165
OMIM
CCDS CCDS23083
HPRD
IMGT
MGI ID MGI:105384
MGI Symbol Hspa8
EMBL AC158355
GenPept
RNA Seq Atlas 15481