Mus musculus Gene: Hspa8 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-153613.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Hspa8 | ||||||||||||||||||||||||||
Gene Name | heat shock protein 8 | ||||||||||||||||||||||||||
Synonyms | 2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10 | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000015656 | ||||||||||||||||||||||||||
Encoded Proteins |
heat shock protein 8
heat shock protein 8
heat shock protein 8
heat shock protein 8
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109971:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 9:40800984-40805200 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | A5.1 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 255 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
mRNA Splicing pathway
Membrane Trafficking pathway
GABA synthesis, release, reuptake and degradation pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cellular responses to stress pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Lysosome Vesicle Biogenesis pathway
Golgi Associated Vesicle Biogenesis pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Neurotransmitter Release Cycle pathway
Attenuation phase pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Gene Expression pathway
Neuronal System pathway
mRNA Splicing - Major Pathway pathway
Regulation of HSF1-mediated heat shock response pathway
Transmission across Chemical Synapses pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
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KEGG |
Antigen processing and presentation pathway
MAPK signaling pathway pathway
Endocytosis pathway
Spliceosome pathway
Protein processing in endoplasmic reticulum pathway
Toxoplasmosis pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
RANKL pathway
TSH pathway
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REACTOME |
AUF1 (hnRNP D0) destabilizes mRNA pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
GABA synthesis, release, reuptake and degradation pathway
Lysosome Vesicle Biogenesis pathway
Golgi Associated Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
CHL1 interactions pathway
L1CAM interactions pathway
Cellular responses to stress pathway
Developmental Biology pathway
trans-Golgi Network Vesicle Budding pathway
Regulation of HSF1-mediated heat shock response pathway
Neuronal System pathway
Attenuation phase pathway
Axon guidance pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
mRNA Splicing pathway
Gene Expression pathway
Membrane Trafficking pathway
Regulation of HSF1-mediated heat shock response pathway
mRNA Splicing - Major Pathway pathway
HSF1-dependent transactivation pathway
mRNA Splicing pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
L1CAM interactions pathway
Cellular responses to stress pathway
Gene Expression pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Axon guidance pathway
Cellular response to heat stress pathway
CHL1 interactions pathway
Attenuation phase pathway
Developmental Biology pathway
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KEGG |
MAPK signaling pathway pathway
Antigen processing and presentation pathway
Endocytosis pathway
Spliceosome pathway
Protein processing in endoplasmic reticulum pathway
Toxoplasmosis pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
C-MYB transcription factor network
Regulation of nuclear SMAD2/3 signaling
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Mm.290774 Mm.336743 Mm.426378 Mm.472965 | ||||||||||||||||||||||||||
RefSeq | NM_031165 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS23083 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||