InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gadd45a

Summary

InnateDB Protein

IDBP-153725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gadd45a

Protein Name

growth arrest and DNA-damage-inducible 45 alpha

Synonyms

AA545191; Ddit1; GADD45;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044034

InnateDB Gene

IDBG-153723 (Gadd45a)

Protein Structure

UniProt Annotation

Function

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. {ECO:0000269PubMed:15735649}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007098	centrosome cycle
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071260	cellular response to mechanical stimulus
GO:0071479	cellular response to ionizing radiation
GO:1900745	positive regulation of p38MAPK cascade
GO:2000379	positive regulation of reactive oxygen species metabolic process