InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fech

Summary

InnateDB Protein

IDBP-153859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fech

Protein Name

ferrochelatase

Synonyms

AI894116; fch; Fcl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025484

InnateDB Gene

IDBG-153857 (Fech)

Protein Structure

UniProt Annotation

Function

Catalyzes the ferrous insertion into protoporphyrin IX.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Note=Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia.

Tissue Specificity

Erythroid and hepatic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0020037	heme binding
GO:0030350	iron-responsive element binding
GO:0046906	tetrapyrrole binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0009416	response to light stimulus
GO:0009589	detection of UV
GO:0010038	response to metal ion
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0010999	regulation of eIF2 alpha phosphorylation by heme
GO:0017085	response to insecticide
GO:0030218	erythrocyte differentiation
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046501	protoporphyrinogen IX metabolic process
GO:0046685	response to arsenic-containing substance
GO:0046984	regulation of hemoglobin biosynthetic process
GO:0051597	response to methylmercury
GO:0055072	iron ion homeostasis
GO:0070541	response to platinum ion
GO:0071549	cellular response to dexamethasone stimulus