Mus musculus Gene: Fech
Summary
InnateDB Gene IDBG-153857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fech
Gene Name ferrochelatase
Synonyms AI894116; fch; Fcl;
Species Mus musculus
Ensembl Gene ENSMUSG00000024588
Encoded Proteins
ferrochelatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066926:
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:64456550-64489066
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000025484 ENSMUSP00000025484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004325 ferrochelatase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0020037 heme binding
GO:0030350 iron-responsive element binding
GO:0046906 tetrapyrrole binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0009416 response to light stimulus
GO:0009589 detection of UV
GO:0010038 response to metal ion
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0017085 response to insecticide
GO:0030218 erythrocyte differentiation
GO:0034379 very-low-density lipoprotein particle assembly
GO:0042493 response to drug
GO:0045471 response to ethanol
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046685 response to arsenic-containing substance
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0051597 response to methylmercury
GO:0055072 iron ion homeostasis
GO:0070541 response to platinum ion
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism pathway
Heme biosynthesis pathway
Metabolism of porphyrins pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Heme biosynthesis pathway
Metabolism of porphyrins pathway
Metabolism pathway
Metabolism of porphyrins pathway
Heme biosynthesis pathway
Metabolism pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
INOH
Porphyrin metabolism pathway
PID BIOCARTA
Hemoglobins chaperone [Biocarta view]
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt P22315
TrEMBL Q544X6 Q8C3V7
UniProt Splice Variant
Entrez Gene 14151
UniGene Mm.412308
RefSeq NM_007998
OMIM
CCDS CCDS29303
HPRD
IMGT
MGI ID MGI:95513
MGI Symbol Fech
EMBL AC102106 AC102268 AK004718 AK018738 AK084843 AK159652 M59288 M61215
GenPept AAA37615 AAA80530 BAB23501 BAB31379 BAC39290 BAE35263
RNA Seq Atlas 14151