InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gucy1a3

Summary

InnateDB Protein

IDBP-154238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gucy1a3

Protein Name

guanylate cyclase 1, soluble, alpha 3

Synonyms

1200016O07Rik; sGC-alpha1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048918

InnateDB Gene

IDBG-154234 (Gucy1a3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0008217	regulation of blood pressure
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction
GO:0052565	response to defense-related host nitric oxide production
GO:0060087	relaxation of vascular smooth muscle

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1926562

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR011644 Heme-NO binding
IPR011645 Haem NO binding associated
IPR024096 NO signalling/Golgi transport ligand-binding domain

PFAM

PF00211
PF07700
PF07701

PRINTS

PIRSF

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERL9