Version 5.4
Mus musculus Protein: Tjp2
Summary
InnateDB Protein IDBP-154442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tjp2
Protein Name tight junction protein 2
Synonyms ZO-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000097154
InnateDB Gene IDBG-154438 (Tjp2)
Protein Structure
UniProt Annotation
Function Plays a role in tight junctions and adherens junctions.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0010033 response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1341872
InterPro IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005419 Zona occludens protein ZO-2
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00018
PF14604
PF00595
PF13180
PF00625
PF07653
PRINTS PR00452
PR01597
PR01599
PIRSF
SMART SM00326
SM00228
SM00072
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0U1
PhosphoSite PhosphoSite-Q9Z0U1
TrEMBL
UniProt Splice Variant
Entrez Gene 21873
UniGene Mm.472626
RefSeq NP_035727
MGI ID 2CSJ
MGI Symbol Tjp2
OMIM
CCDS CCDS37939
HPRD
IMGT
EMBL AF113005 BC034677 BC039924
GenPept AAD19964 AAH34677 AAH39924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca