InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tjp2

Summary

InnateDB Gene

IDBG-154438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tjp2

Gene Name

tight junction protein 2

Synonyms

ZO-2;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024812

Encoded Proteins

IDBP-154442

tight junction protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119139:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:24094523-24225026

Strand

Reverse strand

Band

Transcripts

ENSMUST00000099558

ENSMUSP00000097154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0010033

response to organic substance

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0030054	cell junction

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000119139

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000011770

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_196537

Signaling by Hippo pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu04530

Tight junction pathway

INOH

PID BIOCARTA

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_995

Apoptotic execution phase pathway

REACT_118607

Signaling by Hippo pathway

REACT_578

Apoptosis pathway

REACT_111102

Signal Transduction pathway

REACT_13579

Apoptotic cleavage of cell adhesion proteins pathway

REACT_107

Apoptotic cleavage of cellular proteins pathway

KEGG

hsa04530

Tight junction pathway

hsa05110

Vibrio cholerae infection pathway

INOH

PID BIOCARTA

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

Q9Z0U1

TrEMBL

UniProt Splice Variant

Entrez Gene

21873

UniGene

Mm.104744 Mm.472626

RefSeq

NM_001198985 NM_011597 XM_006526904 XM_006526905 XM_006526906 XM_006526908

OMIM

CCDS

CCDS37939

HPRD

IMGT

MGI ID

MGI:1341872

MGI Symbol

Tjp2

EMBL

AF113005 BC034677 BC039924

GenPept

AAD19964 AAH34677 AAH39924

RNA Seq Atlas

21873