Mus musculus Gene: Tjp2
Summary
InnateDB Gene IDBG-154438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tjp2
Gene Name tight junction protein 2
Synonyms ZO-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000024812
Encoded Proteins
tight junction protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119139:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24094523-24225026
Strand Reverse strand
Band B
Transcripts
ENSMUST00000099558 ENSMUSP00000097154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0010033 response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Apoptotic execution phase pathway
Signaling by Hippo pathway
Apoptosis pathway
Signal Transduction pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
KEGG
Tight junction pathway
Vibrio cholerae infection pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt Q9Z0U1
TrEMBL
UniProt Splice Variant
Entrez Gene 21873
UniGene Mm.104744 Mm.472626
RefSeq NM_001198985 NM_011597 XM_006526904 XM_006526905 XM_006526906 XM_006526908
OMIM
CCDS CCDS37939
HPRD
IMGT
MGI ID MGI:1341872
MGI Symbol Tjp2
EMBL AF113005 BC034677 BC039924
GenPept AAD19964 AAH34677 AAH39924
RNA Seq Atlas 21873