Version 5.4
Mus musculus Gene: Tjp2
Summary
InnateDB Gene IDBG-154438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tjp2
Gene Name tight junction protein 2
Synonyms ZO-2
Species Mus musculus
Ensembl Gene ENSMUSG00000024812
Encoded Proteins
IDBP-154442
tight junction protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119139:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24094523-24225026
Strand Reverse strand
Band B
Transcripts
ENSMUST00000099558 ENSMUSP00000097154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0010033 response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119139
View Gene Order
ENSBTAG00000011770
Not yet available
Pathways
NETPATH
REACTOME
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04530
Tight junction pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt Q9Z0U1
TrEMBL
UniProt Splice Variant
Entrez Gene 21873
UniGene Mm.104744 Mm.472626
RefSeq NM_001198985 NM_011597 XM_006526904 XM_006526905 XM_006526906 XM_006526908
OMIM
CCDS CCDS37939
HPRD
IMGT
MGI ID MGI:1341872
MGI Symbol Tjp2
EMBL AF113005 BC034677 BC039924
GenPept AAD19964 AAH34677 AAH39924
RNA Seq Atlas 21873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca