InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrat

Summary

InnateDB Protein

IDBP-154489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrat

Protein Name

lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

Synonyms

1300010A18Rik; AI449251;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029632

InnateDB Gene

IDBG-154487 (Lrat)

Protein Structure

UniProt Annotation

Function

Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:17114808}; Single-pass membrane protein {ECO:0000269PubMed:17114808}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Hepatic stellate cells and endothelial cells (at protein level). {ECO:0000269PubMed:18544127}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0008374	O-acyltransferase activity
GO:0019841	retinol binding
GO:0047173	phosphatidylcholine-retinol O-acyltransferase activity

Biological Process

GO:0006653	1,2-diacyl-sn-glycero-3-phosphocholine metabolic process
GO:0006776	vitamin A metabolic process
GO:0007601	visual perception
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0050896	response to stimulus

Cellular Component

GO:0005771	multivesicular body
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm