Version 5.4
Mus musculus Protein: Gpaa1
Summary
InnateDB Protein IDBP-154607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpaa1
Protein Name GPI anchor attachment protein 1
Synonyms C80044; mGAA1;
Species Mus musculus
Ensembl Protein ENSMUSP00000023221
InnateDB Gene IDBG-154605 (Gpaa1)
Protein Structure
UniProt Annotation
Function Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269PubMed:10793132, ECO:0000269PubMed:10898732}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,. {ECO:0000269PubMed:10898732}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042765 GPI-anchor transamidase complex
Protein Structure and Domains
PDB ID MGI:1202392
InterPro IPR007246 Gaa1-like, GPI transamidase component
IPR017063 Glycosylphosphatidylinositol:protein transamidase complex, GAA1 component
PFAM PF04114
PRINTS
PIRSF PIRSF036762
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTK3
PhosphoSite PhosphoSite-Q9WTK3
TrEMBL E9QA52
UniProt Splice Variant
Entrez Gene 14731
UniGene Mm.5903
RefSeq NP_034461
MGI ID
MGI Symbol Gpaa1
OMIM
CCDS CCDS37120
HPRD
IMGT
EMBL AB002136 AB002138 AB006970 AB006971 AB017266 AC155074 AK077518 AK164219 AK164978 BC006697
GenPept AAH06697 BAA82586 BAA82589 BAA82591 BAB03274 BAB03275 BAC36840 BAE37686 BAE37988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca