InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgb

Summary

InnateDB Protein

IDBP-154613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgb

Protein Name

fibrinogen beta chain

Synonyms

2510049G14Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039472

InnateDB Gene

IDBG-154611 (Fgb)

Protein Structure

UniProt Annotation

Function

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0050839	cell adhesion molecule binding
GO:0051087	chaperone binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0030168	platelet activation
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0044320	cellular response to leptin stimulus
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0071347	cellular response to interleukin-1
GO:0090277	positive regulation of peptide hormone secretion
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle