Mus musculus Protein: Fgb
Summary
InnateDB Protein IDBP-154613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgb
Protein Name fibrinogen beta chain
Synonyms 2510049G14Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000039472
InnateDB Gene IDBG-154611 (Fgb)
Protein Structure
UniProt Annotation
Function Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0050839 cell adhesion molecule binding
GO:0051087 chaperone binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0030168 platelet activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043623 cellular protein complex assembly
GO:0044320 cellular response to leptin stimulus
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0050714 positive regulation of protein secretion
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071347 cellular response to interleukin-1
GO:0090277 positive regulation of peptide hormone secretion
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0031091 platelet alpha granule
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:99501
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
PFAM PF00147
PF08702
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0E8
PhosphoSite PhosphoSite-Q8K0E8
TrEMBL Q3TGR2
UniProt Splice Variant
Entrez Gene 110135
UniGene Mm.490907
RefSeq NP_862897
MGI ID
MGI Symbol Fgb
OMIM
CCDS CCDS17432
HPRD
IMGT
EMBL AF413205 AK146960 AK168626 BC031715 CH466547
GenPept AAH31715 AAL02225 BAE27567 BAE40486 EDL15421