Mus musculus Gene: Fgb
Summary
InnateDB Gene IDBG-154611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgb
Gene Name fibrinogen beta chain
Synonyms 2510049G14Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000033831
Encoded Proteins
fibrinogen beta chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171564:
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:83042247-83049803
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000048246 ENSMUSP00000039472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0050839 cell adhesion molecule binding
GO:0051087 chaperone binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0030168 platelet activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043623 cellular protein complex assembly
GO:0044320 cellular response to leptin stimulus
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0050714 positive regulation of protein secretion
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071347 cellular response to interleukin-1
GO:0090277 positive regulation of peptide hormone secretion
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0031091 platelet alpha granule
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Integrin cell surface interactions pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Common Pathway pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Integrin cell surface interactions pathway
Common Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
Platelet Aggregation (Plug Formation) pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Fibrinolysis pathway [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta3 integrin cell surface interactions
Cross-References
SwissProt Q8K0E8
TrEMBL Q3TGR2
UniProt Splice Variant
Entrez Gene 110135
UniGene Mm.30063 Mm.490907
RefSeq NM_181849
OMIM
CCDS CCDS17432
HPRD
IMGT
MGI ID MGI:99501
MGI Symbol Fgb
EMBL AF413205 AK146960 AK168626 BC031715 CH466547
GenPept AAH31715 AAL02225 BAE27567 BAE40486 EDL15421
RNA Seq Atlas 110135