InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pip5k1b

Summary

InnateDB Protein

IDBP-154629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pip5k1b

Protein Name

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

Synonyms

PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta; Pipk5b; STM7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025800

InnateDB Gene

IDBG-154627 (Pip5k1b)

Protein Structure

UniProt Annotation

Function

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. {ECO:0000269PubMed:10679324, ECO:0000269PubMed:18772378, ECO:0000269PubMed:8798574}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and testis. Barely detectable in liver and skeletal muscle. {ECO:0000269PubMed:8798574}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity

Biological Process

GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0001931	uropod
GO:0012505	endomembrane system
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107930

InterPro

IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

PFAM

PF01504

PRINTS

PIRSF

SMART

SM00330

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70181

PhosphoSite

PhosphoSite-P70181

TrEMBL

UniProt Splice Variant

Entrez Gene

18719

UniGene

RefSeq

NP_032872

MGI ID

MGI Symbol

Pip5k1b

OMIM

CCDS

CCDS37940

HPRD

IMGT

EMBL

AF048695 AK146100 AK149354 AK164552 BC034864 D86176

GenPept

AAC05374 AAH34864 BAA13030 BAE26901 BAE28830 BAE37836