InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ing2

Summary

InnateDB Protein

IDBP-154720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ing2

Protein Name

inhibitor of growth family, member 2

Synonyms

2810011M06Rik; Ing1l; Ing2b; P33ING2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079226

InnateDB Gene

IDBG-154718 (Ing2)

Protein Structure

UniProt Annotation

Function

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032403	protein complex binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0030317	sperm motility
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0072520	seminiferous tubule development
GO:2001234	negative regulation of apoptotic signaling pathway