Version 5.4
Mus musculus Protein: Grp
Summary
InnateDB Protein IDBP-154843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grp
Protein Name gastrin releasing peptide
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025395
InnateDB Gene IDBG-154841 (Grp)
Protein Structure
UniProt Annotation
Function GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear. {ECO:0000269PubMed:12526815}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus. {ECO:0000269PubMed:12526815}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:95833
InterPro IPR000874 Bombesin/neuromedin-B/ranatensin peptide family
PFAM PF02044
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R1I2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 225642
UniGene Mm.20298
RefSeq NP_778177
MGI ID
MGI Symbol Grp
OMIM
CCDS CCDS29310
HPRD
IMGT
EMBL AK133508 AK139345 BC024515
GenPept AAH24515 BAE21694 BAE23968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca