Mus musculus Gene: Grp
Summary
InnateDB Gene IDBG-154841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grp
Gene Name gastrin releasing peptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024517
Encoded Proteins
gastrin releasing peptide
gastrin releasing peptide
gastrin releasing peptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134443:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:65872820-65886579
Strand Forward strand
Band E1
Transcripts
ENSMUST00000025395 ENSMUSP00000025395
ENSMUST00000173985 ENSMUSP00000133437
ENSMUST00000173530 ENSMUSP00000139014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
GPCR ligand binding pathway
Peptide hormone metabolism pathway
Peptide hormone metabolism pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Incretin synthesis, secretion, and inactivation pathway
Peptide ligand-binding receptors pathway
Signaling by GPCR pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Signal Transduction pathway
Metabolism of proteins pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8R1I2
TrEMBL
UniProt Splice Variant
Entrez Gene 225642
UniGene Mm.20298
RefSeq XM_006525886 XM_006525887 NM_175012
OMIM
CCDS CCDS29310
HPRD
IMGT
MGI ID MGI:95833
MGI Symbol Grp
EMBL AK133508 AK139345 BC024515
GenPept AAH24515 BAE21694 BAE23968
RNA Seq Atlas 225642