InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcbd1

Summary

InnateDB Protein

IDBP-155079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcbd1

Protein Name

pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

Synonyms

Dcoh; Pcbd; Pcd; Phs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020298

InnateDB Gene

IDBG-155077 (Pcbd1)

Protein Structure

UniProt Annotation

Function

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004505	phenylalanine 4-monooxygenase activity
GO:0005515	protein binding
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0043496	regulation of protein homodimerization activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051289	protein homotetramerization
GO:0051291	protein heterooligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:94873

InterPro

IPR001533 Transcriptional coactivator/pterin dehydratase

PFAM

PF01329

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61458

PhosphoSite

PhosphoSite-P61458

TrEMBL

UniProt Splice Variant

Entrez Gene

13180

UniGene

RefSeq

NP_079549

MGI ID

MGI Symbol

Pcbd1

OMIM

CCDS

CCDS35913

HPRD

IMGT

EMBL

AK007401 BC024354 M83741

GenPept

AAH24354 BAB25014