InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPATA13

Summary

InnateDB Protein

IDBP-15527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPATA13

Protein Name

spermatogenesis associated 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343631

InnateDB Gene

IDBG-15519 (SPATA13)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269PubMed:17145773, ECO:0000269PubMed:17599059, ECO:0000269PubMed:19151759, ECO:0000269PubMed:19893577, ECO:0000269PubMed:19934221}.

Subcellular Localization

Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.

Disease Associations

Tissue Specificity

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269PubMed:17145773, ECO:0000269PubMed:17599059, ECO:0000269PubMed:19893577}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity

Biological Process

GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030334	regulation of cell migration
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly