InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Satb2

Summary

InnateDB Protein

IDBP-155569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Satb2

Protein Name

special AT-rich sequence binding protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046067

InnateDB Gene

IDBG-155567 (Satb2)

Protein Structure

UniProt Annotation

Function

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269PubMed:16751105, ECO:0000269PubMed:18255030, ECO:0000269PubMed:18255031}.

Subcellular Localization

Nucleus matrix {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00374}.

Disease Associations

Tissue Specificity

Expressed in cortical neurons that extend axons across the corpus callosum. Also expressed in branchial arches and in cells of the osteoblast lineage, but not in chondrocytes and osteoclasts. {ECO:0000269PubMed:16751105, ECO:0000269PubMed:18255030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	neuron migration
GO:0002076	osteoblast development
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009880	embryonic pattern specification
GO:0010468	regulation of gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0051216	cartilage development
GO:0060021	palate development
GO:0071310	cellular response to organic substance

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016363	nuclear matrix