InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spire1

Summary

InnateDB Protein

IDBP-155574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spire1

Protein Name

spire homolog 1 (Drosophila)

Synonyms

6030430B19Rik; AI415299; AU022898; AW550622; Spir-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080871

InnateDB Gene

IDBG-155570 (Spire1)

Protein Structure

UniProt Annotation

Function

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269PubMed:21620703, ECO:0000269PubMed:21983562}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Punctate spots in perinuclear region and cytoplasm, co- localised with Rab11 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the developing nervous system and in the adult brain, specifically the Purkinje cells of the cerebellum, in neuronal cells in the CA1, CA2 and CA3 fields of the hippocampus and granular layer of the dentate gyrus. Detected in oocytes. {ECO:0000269PubMed:15053972, ECO:0000269PubMed:21620703}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding

Biological Process

GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030036	actin cytoskeleton organization
GO:0036089	cleavage furrow formation
GO:0040038	polar body extrusion after meiotic divisions
GO:0046907	intracellular transport
GO:0048193	Golgi vesicle transport
GO:0051295	establishment of meiotic spindle localization
GO:0070649	formin-nucleated actin cable assembly

Cellular Component

GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0030659	cytoplasmic vesicle membrane
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm