InnateDB Protein
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IDBP-155574.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Spire1
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Protein Name
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spire homolog 1 (Drosophila)
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Synonyms
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6030430B19Rik; AI415299; AU022898; AW550622; Spir-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000080871
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InnateDB Gene
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IDBG-155570 (Spire1)
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Protein Structure
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Function |
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269PubMed:21620703, ECO:0000269PubMed:21983562}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Punctate spots in perinuclear region and cytoplasm, co- localised with Rab11 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the developing nervous system and in the adult brain, specifically the Purkinje cells of the cerebellum, in neuronal cells in the CA1, CA2 and CA3 fields of the hippocampus and granular layer of the dentate gyrus. Detected in oocytes. {ECO:0000269PubMed:15053972, ECO:0000269PubMed:21620703}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915416
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InterPro |
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q52KF3
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PhosphoSite |
PhosphoSite-Q52KF3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68166
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UniGene |
Mm.400948
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RefSeq |
XP_006526268
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MGI ID |
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MGI Symbol |
Spire1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC046486
BC058669
BC094375
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GenPept |
AAH46486
AAH58669
AAH94375
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