Version 5.4
Mus musculus Gene: Spire1
Summary
InnateDB Gene IDBG-155570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spire1
Gene Name spire homolog 1 (Drosophila)
Synonyms 6030430B19Rik; AI415299; AU022898; AW550622; Spir-1
Species Mus musculus
Ensembl Gene ENSMUSG00000024533
Encoded Proteins
IDBP-155572
spire homolog 1 (Drosophila)
IDBP-155574
spire homolog 1 (Drosophila)
IDBP-250473
spire homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134278:
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:67488209-67552777
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000045105 ENSMUSP00000049336
ENSMUST00000082243 ENSMUSP00000080871
ENSMUST00000115050 ENSMUSP00000110702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030036 actin cytoskeleton organization
GO:0036089 cleavage furrow formation
GO:0040038 polar body extrusion after meiotic divisions
GO:0046907 intracellular transport
GO:0048193 Golgi vesicle transport
GO:0051295 establishment of meiotic spindle localization
GO:0070649 formin-nucleated actin cable assembly
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0030659 cytoplasmic vesicle membrane
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134278
View Gene Order
ENSBTAG00000010542
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt Q52KF3
TrEMBL D3YTL8 D3Z495
UniProt Splice Variant
Entrez Gene 68166
UniGene Mm.208723 Mm.400948
RefSeq NM_176832 NM_194355 XM_006526204 XM_006526205 XM_006526206 XM_006526207
OMIM
CCDS CCDS29323 CCDS37849
HPRD
IMGT
MGI ID MGI:1915416
MGI Symbol Spire1
EMBL AC120410 BC046486 BC058669 BC094375
GenPept AAH46486 AAH58669 AAH94375
RNA Seq Atlas 68166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca