InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rel

Summary

InnateDB Protein

IDBP-155650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rel

Protein Name

reticuloendotheliosis oncogene

Synonyms

c-Rel;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099928

InnateDB Gene

IDBG-155648 (Rel)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	23 [view]
Protein-DNA	34 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	82 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001816	cytokine production
GO:0006355	regulation of transcription, DNA-templated
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:97897

InterPro

IPR000451 NF-kappa-B/Rel/Dorsal
IPR002909 IPT domain
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR00057

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt