InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdlim7

Summary

InnateDB Protein

IDBP-156140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdlim7

Protein Name

PDZ and LIM domain 7

Synonyms

LMP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064219

InnateDB Gene

IDBG-156136 (Pdlim7)

Protein Structure

UniProt Annotation

Function

May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001503	ossification
GO:0007275	multicellular organismal development
GO:0030036	actin cytoskeleton organization
GO:0030154	cell differentiation
GO:0045669	positive regulation of osteoblast differentiation