InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itpr3

Summary

InnateDB Protein

IDBP-156296.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpr3

Protein Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

Ip3r3; Itpr-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038150

InnateDB Gene

IDBG-156294 (Itpr3)

Protein Structure

UniProt Annotation

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. {ECO:0000269PubMed:20813840, ECO:0000269PubMed:21030605}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15632133, ECO:0000269PubMed:21030605}; Multi- pass membrane protein {ECO:0000269PubMed:15632133, ECO:0000269PubMed:21030605}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007613	memory
GO:0045087	innate immune response (InnateDB)
GO:0048016	inositol phosphate-mediated signaling
GO:0050913	sensory perception of bitter taste
GO:0050916	sensory perception of sweet taste
GO:0050917	sensory perception of umami taste
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060291	long-term synaptic potentiation
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:96624

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016024 Armadillo-type fold
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt