Mus musculus Gene: Itpr3
Summary
InnateDB Gene IDBG-156294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itpr3
Gene Name inositol 1,4,5-triphosphate receptor 3
Synonyms Ip3r3; Itpr-3;
Species Mus musculus
Ensembl Gene ENSMUSG00000042644
Encoded Proteins
inositol 1,4,5-triphosphate receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Itpr3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ITPR3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096433:
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27057304-27122223
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000049308 ENSMUSP00000038150
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005218 intracellular ligand-gated calcium channel activity
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007613 memory
GO:0045087 innate immune response (InnateDB)
GO:0048016 inositol phosphate-mediated signaling
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0060291 long-term synaptic potentiation
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
Disease pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Integration of energy metabolism pathway
Role of phospholipids in phagocytosis pathway
Signaling by VEGF pathway
Platelet calcium homeostasis pathway
Signaling by FGFR in disease pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
beta-catenin independent WNT signaling pathway
VEGFR2 mediated cell proliferation pathway
PLC-gamma1 signalling pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Regulation of insulin secretion pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Effects of PIP2 hydrolysis pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
Ca2+ pathway pathway
FCERI mediated Ca+2 mobilization pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Elevation of cytosolic Ca2+ levels pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
Taste transduction pathway
GnRH signaling pathway pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Alzheimer's disease pathway
INOH
GPCR signaling pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Phospholipase C-mediated cascade pathway
beta-catenin independent WNT signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Platelet calcium homeostasis pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
Platelet activation, signaling and aggregation pathway
Role of phospholipids in phagocytosis pathway
PLC-gamma1 signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Opioid Signalling pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Adaptive Immune System pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Immune System pathway
Platelet homeostasis pathway
Downstream signal transduction pathway
VEGFR2 mediated cell proliferation pathway
Elevation of cytosolic Ca2+ levels pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Effects of PIP2 hydrolysis pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signaling by FGFR pathway
Regulation of insulin secretion pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Metabolism pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
PLCG1 events in ERBB2 signaling pathway
Disease pathway
Hemostasis pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
Taste transduction pathway
GnRH signaling pathway pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Alzheimer's disease pathway
INOH
GPCR signaling pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P70227
TrEMBL Q922U9
UniProt Splice Variant
Entrez Gene 16440
UniGene Mm.328900 Mm.458106
RefSeq NM_080553
OMIM
CCDS CCDS28560
HPRD
IMGT
MGI ID MGI:96624
MGI Symbol Itpr3
EMBL AB182289 AK028491 BC006773 BC010323 M90088 Z71174
GenPept AAH06773 AAH10323 BAC25977 BAD90683 CAA94862
RNA Seq Atlas 16440