InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc1a1

Summary

InnateDB Protein

IDBP-156519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc1a1

Protein Name

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Synonyms

D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025875

InnateDB Gene

IDBG-156517 (Slc1a1)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain, lung, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0015501	glutamate:sodium symporter activity
GO:0016595	glutamate binding
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006835	dicarboxylic acid transport
GO:0015813	L-glutamate transport
GO:0051260	protein homooligomerization
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import