Mus musculus Gene: Slc1a1
Summary
InnateDB Gene IDBG-156517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc1a1
Gene Name solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1;
Species Mus musculus
Ensembl Gene ENSMUSG00000024935
Encoded Proteins
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106688:
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:28835049-28913960
Strand Forward strand
Band C1
Transcripts
ENSMUST00000025875 ENSMUSP00000025875
ENSMUST00000161340
ENSMUST00000161119
ENSMUST00000160702
ENSMUST00000162189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0015501 glutamate:sodium symporter activity
GO:0016595 glutamate binding
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006835 dicarboxylic acid transport
GO:0015813 L-glutamate transport
GO:0051260 protein homooligomerization
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Neurotransmitter Release Cycle pathway
Transmembrane transport of small molecules pathway
Neuronal System pathway
Glutamate Neurotransmitter Release Cycle pathway
Transmission across Chemical Synapses pathway
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Neuronal System pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Glutamate Neurotransmitter Release Cycle pathway
SLC-mediated transmembrane transport pathway
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.246670 Mm.400146
RefSeq NM_009199
OMIM
CCDS CCDS29727
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas