Version 5.4
Mus musculus Protein: Crat
Summary
InnateDB Protein IDBP-156669.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crat
Protein Name carnitine acetyltransferase
Synonyms AW107812; CARAT;
Species Mus musculus
Ensembl Protein ENSMUSP00000099919
InnateDB Gene IDBG-156667 (Crat)
Protein Structure
UniProt Annotation
Function Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Subcellular Localization Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004092 carnitine O-acetyltransferase activity
GO:0005102 receptor binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006810 transport
GO:0019254 carnitine metabolic process, CoA-linked
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:109501
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
PFAM PF00755
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47934
PhosphoSite PhosphoSite-P47934
TrEMBL H7BX88
UniProt Splice Variant
Entrez Gene 12908
UniGene Mm.20396
RefSeq XP_006497708
MGI ID 2H3W
MGI Symbol Crat
OMIM
CCDS CCDS15882
HPRD
IMGT
EMBL AK132179 AK170740 AL954299 AL954388 BC006668 X85983
GenPept AAH06668 BAE21016 BAE41993 CAA59971 CAM23162 CAM23291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca