InnateDB Protein
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IDBP-156678.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tcf4
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Protein Name
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transcription factor 4
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Synonyms
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5730422P05Rik; ASP-I2; bHLHb19; E2-2; E2.2; ITF-2; ITF-2b; ITF2; ME2; MITF-2A; MITF-2B; SEF-2; SEF2; SEF2-1; Tcf-4; TFE;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077577
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InnateDB Gene
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IDBG-156674 (Tcf4)
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Protein Structure
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Function |
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha-actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity. {ECO:0000269PubMed:18214987}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in the cerebral cortex, Purkinje and granule cell layers of the cerebellum, olfactory neuroepithelium, pyramidal cells of hippocampal layers CA1-CA4, and in the granular cells of the dentate gyrus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
57 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001011
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sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0001087
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TFIIB-class binding transcription factor activity
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GO:0001093
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TFIIB-class transcription factor binding
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GO:0003677
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DNA binding
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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GO:0070888
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E-box binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006352
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DNA-templated transcription, initiation
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0045666
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positive regulation of neuron differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0065004
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protein-DNA complex assembly
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Cellular Component |
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PDB ID |
MGI:98506
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q60722
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PhosphoSite |
PhosphoSite-Q60722
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21413
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UniGene |
Mm.485755
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RefSeq |
XP_006525809
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MGI ID |
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MGI Symbol |
Tcf4
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OMIM |
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CCDS |
CCDS29329
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HPRD |
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IMGT |
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EMBL |
AK081012
BC043050
S75870
U16321
U16322
X91753
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GenPept |
AAB32662
AAC52414
AAC52415
AAH43050
BAC38116
CAA62868
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