InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrpap1

Summary

InnateDB Protein

IDBP-156702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrpap1

Protein Name

low density lipoprotein receptor-related protein associated protein 1

Synonyms

AA617339; AI790446; AU042172; C77774; HBP44; RAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030986

InnateDB Gene

IDBG-156700 (Lrpap1)

Protein Structure

UniProt Annotation

Function

Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

Subcellular Localization

Endoplasmic reticulum {ECO:0000255PROSITE- ProRule:PRU10138}. Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells. {ECO:0000269PubMed:2229028}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0035473	lipase binding
GO:0048019	receptor antagonist activity
GO:0050750	low-density lipoprotein particle receptor binding
GO:0070326	very-low-density lipoprotein particle receptor binding

Biological Process

GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0032091	negative regulation of protein binding
GO:1900116	extracellular negative regulation of signal transduction
GO:1900222	negative regulation of beta-amyloid clearance

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031982	vesicle
GO:0048237	rough endoplasmic reticulum lumen