Version 5.4
Mus musculus Protein: Gpt
Summary
InnateDB Protein IDBP-156800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpt
Protein Name glutamic pyruvic transaminase, soluble
Synonyms 1300007J06Rik; 2310022B03Rik; ALT; Gpt-1; Gpt1;
Species Mus musculus
Ensembl Protein ENSMUSP00000023203
InnateDB Gene IDBG-156798 (Gpt)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in liver, intestine, colon and white adipose tissue. {ECO:0000269PubMed:15122758}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
GO:0042853 L-alanine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:95802
InterPro IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZR5
PhosphoSite PhosphoSite-Q8QZR5
TrEMBL Q566C3
UniProt Splice Variant
Entrez Gene 76282
UniGene
RefSeq NP_877957
MGI ID
MGI Symbol Gpt
OMIM
CCDS CCDS27586
HPRD
IMGT
EMBL BC022625 BC026846 BK005127 CH466545
GenPept AAH22625 AAH26846 DAA05289 EDL29605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca