InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F8

Summary

InnateDB Protein

IDBP-157126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

coagulation factor VIII

Synonyms

Cf-8; Cf8; FVIII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033539

InnateDB Gene

IDBG-157124 (F8)

Protein Structure

UniProt Annotation

Function

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Found in most tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006508	proteolysis
GO:0006953	acute-phase response
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0030168	platelet activation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:88383

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR008972 Cupredoxin
IPR008979 Galactose-binding domain-like
IPR011706 Multicopper oxidase, type 2
IPR011707 Multicopper oxidase, type 3

PFAM

PF00754
PF07731
PF07732

PRINTS

PIRSF

SMART

SM00231

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q06194