InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBPMS

Summary

InnateDB Protein

IDBP-15731.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBPMS

Protein Name

RNA binding protein with multiple splicing

Synonyms

HERMES;

Species

Homo sapiens

Ensembl Protein

ENSP00000287771

InnateDB Gene

IDBG-15727 (RBPMS)

Protein Structure

UniProt Annotation

Function

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. {ECO:0000269PubMed:17099224}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17099224}. Cytoplasm {ECO:0000269PubMed:17099224}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	positive regulation of SMAD protein import into nucleus