InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGXT2

Summary

InnateDB Protein

IDBP-15743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGXT2

Protein Name

alanine--glyoxylate aminotransferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000231420

InnateDB Gene

IDBG-15739 (AGXT2)

Protein Structure

UniProt Annotation

Function

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269PubMed:20018850, ECO:0000269PubMed:23023372}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:20018850}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008453	alanine-glyoxylate transaminase activity
GO:0008483	transaminase activity
GO:0016223	beta-alanine-pyruvate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0047305	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
GO:0019481	L-alanine catabolic process, by transamination
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0046487	glyoxylate metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process