Homo sapiens Gene: AGXT2
Summary
InnateDB Gene IDBG-15739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGXT2
Gene Name alanine--glyoxylate aminotransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113492
Encoded Proteins
alanine--glyoxylate aminotransferase 2
alanine--glyoxylate aminotransferase 2
alanine--glyoxylate aminotransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:34998101-35048135
Strand Reverse strand
Band p13.2
Transcripts
ENST00000231420 ENSP00000231420
ENST00000512135
ENST00000510428 ENSP00000422799
ENST00000505349
ENST00000505542
ENST00000618015 ENSP00000479154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016223 beta-alanine-pyruvate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0008152 metabolic process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0019481 L-alanine catabolic process, by transamination
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0046487 glyoxylate metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyrimidine catabolism pathway
Pyrimidine metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism of nucleotides pathway
Glyoxylate metabolism pathway
Metabolism pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Glycine, serine and threonine metabolism pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
Glycine Serine metabolism pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PDL7
UniProt Splice Variant
Entrez Gene 64902
UniGene
RefSeq NM_031900 XM_005248337
HUGO HGNC:14412
OMIM 612471
CCDS CCDS3908
HPRD
IMGT
EMBL AC010368
GenPept
RNA Seq Atlas 64902