InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AGXT2

Summary

InnateDB Gene

IDBG-15739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGXT2

Gene Name

alanine--glyoxylate aminotransferase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000113492

Encoded Proteins

IDBP-15743

alanine--glyoxylate aminotransferase 2

IDBP-481317

alanine--glyoxylate aminotransferase 2

IDBP-807124

alanine--glyoxylate aminotransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:34998101-35048135

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000231420	ENSP00000231420
ENST00000512135
ENST00000510428	ENSP00000422799
ENST00000505349
ENST00000505542
ENST00000618015	ENSP00000479154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008453	alanine-glyoxylate transaminase activity
GO:0008483	transaminase activity
GO:0016223	beta-alanine-pyruvate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0047305	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0008152	metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
GO:0019481	L-alanine catabolic process, by transamination
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0046487	glyoxylate metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000089678

View Gene Order

ENSBTAG00000007690

Not yet available

Pathways

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_1023

Pyrimidine catabolism pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_957

Pyrimidine metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00250

Alanine, aspartate and glutamate metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

INOH website

Alanine Aspartate Asparagine metabolism pathway

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.34494

RefSeq

NM_031900 XM_005248337

HUGO

OMIM

CCDS

CCDS3908

HPRD

10638

IMGT

EMBL

GenPept

RNA Seq Atlas