InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lipe

Summary

InnateDB Protein

IDBP-157572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipe

Protein Name

lipase, hormone sensitive

Synonyms

4933403G17Rik; HSL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003207

InnateDB Gene

IDBG-157570 (Lipe)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0016298	lipase activity
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0033878	hormone-sensitive lipase activity
GO:0042134	rRNA primary transcript binding

Biological Process

GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008152	metabolic process
GO:0008203	cholesterol metabolic process
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0046340	diacylglycerol catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005901	caveola

Protein Structure and Domains

PDB ID

MGI:96790

InterPro

IPR010468 Hormone-sensitive lipase, N-terminal
IPR013094 Alpha/beta hydrolase fold-3
IPR019436 Steryl acetyl hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF06350
PF07859
PF10340

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54310

PhosphoSite