InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SF3A2

Summary

InnateDB Protein

IDBP-15769.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF3A2

Protein Name

splicing factor 3a, subunit 2, 66kDa

Synonyms

PRP11; PRPF11; SAP62; SF3a66;

Species

Homo sapiens

Ensembl Protein

ENSP00000221494

InnateDB Gene

IDBG-15767 (SF3A2)

Protein Structure

UniProt Annotation

Function

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00130}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 152 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	152 [view]
Protein-Protein	151 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000389	mRNA 3'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0030532	small nuclear ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome