InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPCAT3

Summary

InnateDB Protein

IDBP-15808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPCAT3

Protein Name

lysophosphatidylcholine acyltransferase 3

Synonyms

C3F; LPCAT; LPLAT 5; LPSAT; MBOAT5; nessy; OACT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000261407

InnateDB Gene

IDBG-15806 (LPCAT3)

Protein Structure

UniProt Annotation

Function

Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18195019, ECO:0000269PubMed:18772128}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18195019}; Multi-pass membrane protein {ECO:0000269PubMed:18195019}.

Disease Associations

Tissue Specificity

Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils. {ECO:0000269PubMed:18195019, ECO:0000269PubMed:18772128}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0097006	regulation of plasma lipoprotein particle levels