Mus musculus Protein: Abl1 | |||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-158220.6 | ||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
Gene Symbol | Abl1 | ||||||||||||||||||||||||||||||||||||||
Protein Name | c-abl oncogene 1, non-receptor tyrosine kinase | ||||||||||||||||||||||||||||||||||||||
Synonyms | Abl; AI325092; c-Abl; E430008G22Rik; | ||||||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000028190 | ||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-158216 (Abl1) | ||||||||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||||||||||
Function | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage- induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. {ECO:0000269PubMed:11279004, ECO:0000269PubMed:11279131, ECO:0000269PubMed:11350980, ECO:0000269PubMed:12107171, ECO:0000269PubMed:12748290, ECO:0000269PubMed:14993293, ECO:0000269PubMed:19878872, ECO:0000269PubMed:19903482, ECO:0000269PubMed:7780740, ECO:0000269PubMed:8194526, ECO:0000269PubMed:9109492}. | ||||||||||||||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=The myristoylated c-ABL protein is reported to be nuclear. Sequestered into the cytoplasm through interaction with 14-3-3 proteins (By similarity). Localizes to mitochondria in response to oxidative stress. {ECO:0000250}. | ||||||||||||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||||||||||||
Tissue Specificity | Widely expressed. | ||||||||||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 268 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||||||||||
PDB ID | MGI:87859 | ||||||||||||||||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR000980 SH2 domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001452 SH3 domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR011511 Variant SH3 domain IPR015015 F-actin binding IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00017 PF14633 PF07714 PF00018 PF14604 PF07653 PF08919 |
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PRINTS |
PR00401
PR00109 PR00452 |
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PIRSF | |||||||||||||||||||||||||||||||||||||||
SMART |
SM00252
SM00326 SM00220 SM00808 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||||||
SwissProt | P00520 | ||||||||||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P00520 | ||||||||||||||||||||||||||||||||||||||
TrEMBL | Q3V2W1 | ||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
Entrez Gene | 11350 | ||||||||||||||||||||||||||||||||||||||
UniGene | Mm.1318 | ||||||||||||||||||||||||||||||||||||||
RefSeq | NP_033724 | ||||||||||||||||||||||||||||||||||||||
MGI ID | 3OY3 | ||||||||||||||||||||||||||||||||||||||
MGI Symbol | Abl1 | ||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||
CCDS | CCDS15901 | ||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||
EMBL | AK088252 AK090095 BC059260 J02995 K03228 M12263 M12264 M12265 M12266 U13835 U14720 U14721 X07539 X07540 X07541 | ||||||||||||||||||||||||||||||||||||||
GenPept | AAA37134 AAA37135 AAA37136 AAA37137 AAA37138 AAA88241 AAB60448 AAB60449 AAB60450 AAB60451 AAH59260 BAC41088 BAE43394 CAA30411 CAA30412 CAA30413 CAA30414 | ||||||||||||||||||||||||||||||||||||||