InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpe

Summary

InnateDB Protein

IDBP-158254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpe

Protein Name

carboxypeptidase E

Synonyms

CPH; Cph-1; Cph1; fat; R74677;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048555

InnateDB Gene

IDBG-158252 (Cpe)

Protein Structure

UniProt Annotation

Function

Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. This binding is Ca(2+)-dependent (By similarity). {ECO:0000250}.

Disease Associations

Note=Defects in Cpe are the cause of the fat phenotype. Mice homozygous for the fat mutation develop obesity and hyperglycemia that can be suppressed by treatment with exogenous insulin.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding
GO:0042043	neurexin family protein binding
GO:0050839	cell adhesion molecule binding