InnateDB Protein
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IDBP-158254.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cpe
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Protein Name
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carboxypeptidase E
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Synonyms
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CPH; Cph-1; Cph1; fat; R74677;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000048555
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InnateDB Gene
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IDBG-158252 (Cpe)
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Protein Structure
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Function |
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. This binding is Ca(2+)-dependent (By similarity). {ECO:0000250}.
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Disease Associations |
Note=Defects in Cpe are the cause of the fat phenotype. Mice homozygous for the fat mutation develop obesity and hyperglycemia that can be suppressed by treatment with exogenous insulin.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:101932
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InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
IPR008969
Carboxypeptidase-like, regulatory domain
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PFAM |
PF00246
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PRINTS |
PR00765
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PIRSF |
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SMART |
SM00631
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TIGRFAMs |
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Modification |
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SwissProt |
Q00493
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q543R4
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UniProt Splice Variant |
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Entrez Gene |
12876
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UniGene |
Mm.470333
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RefSeq |
NP_038522
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MGI ID |
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MGI Symbol |
Cpe
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OMIM |
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CCDS |
CCDS22327
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HPRD |
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IMGT |
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EMBL |
AK047891
BC010197
U23184
X61232
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GenPept |
AAB60488
AAH10197
BAC33184
CAA43550
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