Mus musculus Gene: Cpe
Summary
InnateDB Gene IDBG-158252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpe
Gene Name carboxypeptidase E
Synonyms CPH; Cph-1; Cph1; fat; R74677;
Species Mus musculus
Ensembl Gene ENSMUSG00000037852
Encoded Proteins
carboxypeptidase E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109472:
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:64592558-64693040
Strand Reverse strand
Band B3.1
Transcripts
ENSMUST00000048967 ENSMUSP00000048555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
GO:0042043 neurexin family protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0003214 cardiac left ventricle morphogenesis
GO:0006508 proteolysis
GO:0030070 insulin processing
GO:0072657 protein localization to membrane
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0030658 transport vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Peptide hormone metabolism pathway
Insulin processing pathway
KEGG
Type I diabetes mellitus pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of proteins pathway
Insulin processing pathway
Peptide hormone metabolism pathway
Peptide hormone metabolism pathway
Metabolism of proteins pathway
Insulin processing pathway
KEGG
Type I diabetes mellitus pathway
INOH
PID BIOCARTA
PID NCI
Arf6 trafficking events
Cross-References
SwissProt Q00493
TrEMBL Q543R4
UniProt Splice Variant
Entrez Gene 12876
UniGene Mm.31395 Mm.470333
RefSeq NM_013494
OMIM
CCDS CCDS22327
HPRD
IMGT
MGI ID MGI:101932
MGI Symbol Cpe
EMBL AK047891 BC010197 U23184 X61232
GenPept AAB60488 AAH10197 BAC33184 CAA43550
RNA Seq Atlas 12876