InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cpe

Summary

InnateDB Gene

IDBG-158252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpe

Gene Name

carboxypeptidase E

Synonyms

CPH; Cph-1; Cph1; fat; R74677

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037852

Encoded Proteins

IDBP-158254

carboxypeptidase E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109472:
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:64592558-64693040

Strand

Reverse strand

Band

B3.1

Transcripts

ENSMUST00000048967

ENSMUSP00000048555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding
GO:0042043	neurexin family protein binding
GO:0050839	cell adhesion molecule binding