InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: A1cf

Summary

InnateDB Protein

IDBP-158363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

A1cf

Protein Name

APOBEC1 complementation factor

Synonyms

1810073H04Rik; Acf; ACF64; ACF65; ASP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075235

InnateDB Gene

IDBG-158361 (A1cf)

Protein Structure

UniProt Annotation

Function

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). {ECO:0000250UniProtKB:Q9NQ94}.

Subcellular Localization

Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed primarily in liver, small intestine and kidney. {ECO:0000269PubMed:15451168}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0016554	cytidine to uridine editing
GO:0050821	protein stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0030895	apolipoprotein B mRNA editing enzyme complex

Protein Structure and Domains

PDB ID

MGI:1917115

InterPro

IPR000504 RNA recognition motif domain
IPR006535 HnRNP R/Q splicing factor

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5YD48

PhosphoSite

PhosphoSite-Q5YD48

TrEMBL

UniProt Splice Variant

Entrez Gene

69865

UniGene

Mm.87538

RefSeq

NP_001074543

MGI ID

MGI Symbol

A1cf

OMIM

CCDS

CCDS37959

HPRD

IMGT

EMBL

AC117816 AC125019 AY566862 AY566863 AY566864 BC089622

GenPept

AAH89622 AAT74916 AAT74917 AAT74918