InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fkbp5

Summary

InnateDB Protein

IDBP-158518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp5

Protein Name

FK506 binding protein 5

Synonyms

D17Ertd592e; Dit1; FKBP-5; FKBP51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078382

InnateDB Gene

IDBG-158514 (Fkbp5)

Protein Structure

UniProt Annotation

Function

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11751894}. Nucleus {ECO:0000269PubMed:11751894}.

Disease Associations

Tissue Specificity

Widely expressed, highest levels found in the liver, skeletal muscle, kidney and thymus. Expression is regulated during adipocyte differentiation.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0031072	heat shock protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0018208	peptidyl-proline modification
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:104670

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64378