Version 5.4
Mus musculus Protein: Minpp1
Summary
InnateDB Protein IDBP-158645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Minpp1
Protein Name multiple inositol polyphosphate histidine phosphatase 1
Synonyms AA408516;
Species Mus musculus
Ensembl Protein ENSMUSP00000025827
InnateDB Gene IDBG-158643 (Minpp1)
Protein Structure
UniProt Annotation
Function Acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3- BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate (By similarity). Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). May play a role in bone development (endochondral ossification). {ECO:0000250, ECO:0000269PubMed:10938126}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}. Cell membrane {ECO:0000305PubMed:10938126}. Note=Also attached to the plasma membrane in erythrocytes. {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in kidney, intestine, thymus and liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
GO:0016791 phosphatase activity
GO:0034417 bisphosphoglycerate 3-phosphatase activity
GO:0052826 inositol hexakisphosphate 2-phosphatase activity
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1336159
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
IPR016274 Histidine acid phosphatase, eukaryotic
IPR029033 Histidine phosphatase superfamily
PFAM PF00328
PRINTS
PIRSF PIRSF000894
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2L6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 17330
UniGene Mm.398664
RefSeq NP_034929
MGI ID
MGI Symbol Minpp1
OMIM
CCDS CCDS29751
HPRD
IMGT
EMBL AB041574 AF046908 AK151486 BC021437
GenPept AAD02434 AAH21437 BAA95058 BAE30439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca